liver cancer and its use with retinoids and chemotherapy in APL. Företaget torsade de pointes during induction therapy for relapsed APL with arsenic trioxide.
Other warnings: Arsenic trioxide is a human carcinogen and has the potential to lead to secondary dexamethasone prior to chemotherapy administration.
Updated on January 21, 2020 Arsenic trioxide—also known as ATO, or trisenox—is an anticancer treatment for a subtype of acute myeloid leukemia known as acute promyelocytic leukemia, or APL. This leukemia subtype is also called “the M3 subtype” of acute myeloid leukemia. It is also used to treat APL in certain people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with a retinoid and other types of chemotherapy treatment(s). Arsenic trioxide is in a class of medications called anti-neoplastics. As all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are widely accepted in treating acute promyelocytic leukemia (APL), deescalating toxicity becomes a research hotspot. Here, we evaluated whether chemotherapy could be replaced or reduced by ATO in APL patients at different risks.
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INTRODUCTION Small cell lung cancer (SCLC) carries high mortality despite standard chemotherapy. Arsenic trioxide (ATO) has demonstrated clinical efficacy in leukemia and in vitro activity in various solid tumors. This study was conducted to determine the in vitro and in vivo combination effects of ATO and chemotherapy in SCLC. MATERIALS AND METHODS The in vitro model consisted of 5 SCLC cell CONCLUSIONS: Arsenic trioxide is effective as first-line treatment for APL. Results of arsenic trioxide combination therapy with chemotherapy/ATRA requires further study. PMID: 16227315 [Indexed for MEDLINE] MeSH terms. Adolescent; Adult; Aged; Antineoplastic Agents/therapeutic use* Arsenic Trioxide; Arsenicals/therapeutic use* Child; Disease-Free Survival; Female Introduction: Arsenic trioxide is effective and approved for treatment of relapsed or refractory acute promyelocytic leukemia (APL) cases resistant to all-trans retinoic acid (ATRA), but its effect on new cases of APL is not clear.
ATRA+ Arsenic trioxide combination 2) Arsenic trioxide, As O, 2 3.
Arsenic trioxide (Trisenox, ATO) Arsenic trioxide is a chemotherapy drug and is also called Trisenox or ATO. It is a treatment for a type of acute myeloid leukaemia called acute promyelocytic leukaemia (APL).
The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind As2O3 toxicity. Arsenic Trioxide may be temporarily discontinued in the presence of o Differentiation syndrome (Table 1) o Hepatotoxicity (Table 1) o QT prolongation on ECG (see Arsenic Trioxide and QT prolongation below) Arsenic Trioxide will need to be discontinued permanently in the event of cardiac arrhythmias or severe neurological toxicity.
arrowhead/MS arrowroot/MS arroyo/SM arsenal/SM arsenate/M arsenic/MS chemotherapy/SM chemurgy/SM chenille/MS cherish/DRSG cherisher/M trio/MS triode/SM trioxide/M trip/MYS tripartite/N tripartition/M tripe/SM triphenylarsine
In particular, the compulsory use of prednisone (or prednisolone) as prophylactic therapy and the delayed introduction of arsenic trioxide on day 9 of the induction therapy was expected to almost completely eliminate the severest form of APL differentiation syndrome.
15 mars 2021 — or treatment with chemotherapy and/or radiation for other diseases.
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Arsenic trioxide can harm an unborn baby if the mother or the father is using this medicine.
some types of acute myeloid leukemia.
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Arsenic Trioxide as Effective Therapy for Relapsed Acute Promyelocytic acid ( ATRA) plus anthracycline-based cytotoxic chemotherapy, a combination that is
Introduction: Arsenic trioxide is effective and approved for treatment of relapsed or refractory acute promyelocytic leukemia (APL) cases resistant to all-trans retinoic acid (ATRA), but its effect on new cases of APL is not clear. Materials and methods: We studied 111 patients with APL. Arsenic trioxide is used to treat cancer. It is given in the vein (IV).